Title : Capsaicin and Piperine Can Overcome Multidrug Resistance in Cancer Cells to Doxorubicin.

Pub. Date : 2018 Mar 2

PMID : 29498663






3 Functional Relationships(s)
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1 We analyzed the ability of two pungent-tasting alkaloids-capsaicin and piperine from Capsicum frutescens and Piper nigrum, respectively-to reverse multidrug resistance in the cancer cell lines Caco-2 and CEM/ADR 5000, which overexpress P-glycoprotein (P-gp) and other ABC transporters. Alkaloids ATP binding cassette subfamily B member 1 Homo sapiens
2 We analyzed the ability of two pungent-tasting alkaloids-capsaicin and piperine from Capsicum frutescens and Piper nigrum, respectively-to reverse multidrug resistance in the cancer cell lines Caco-2 and CEM/ADR 5000, which overexpress P-glycoprotein (P-gp) and other ABC transporters. Alkaloids ATP binding cassette subfamily B member 1 Homo sapiens
3 Furthermore, rhodamine (Rho) 123 and calcein-AM were used to detect the effects of alkaloids on the activity of P-gp. Alkaloids ATP binding cassette subfamily B member 1 Homo sapiens