Title : A CREB-mediated increase in miRNA let-7f during prolonged β-agonist exposure: a novel mechanism of β2-adrenergic receptor down-regulation in airway smooth muscle.

Pub. Date : 2018 Jul

PMID : 29455573






3 Functional Relationships(s)
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1 Thus, beta2AR down-regulation occurs as a result of not only internalized receptor degradation but also a novel cAMP/PKA/CREB-mediated increase in let-7f, which causes enhanced repression of the beta2AR gene, adrenoreceptor beta2 ( ADRB2) translation and represents ~50% of the net loss of receptors observed after prolonged agonist exposure. Cyclic AMP adrenoceptor beta 2 Homo sapiens
2 Thus, beta2AR down-regulation occurs as a result of not only internalized receptor degradation but also a novel cAMP/PKA/CREB-mediated increase in let-7f, which causes enhanced repression of the beta2AR gene, adrenoreceptor beta2 ( ADRB2) translation and represents ~50% of the net loss of receptors observed after prolonged agonist exposure. Cyclic AMP adrenoceptor beta 2 Homo sapiens
3 Thus, beta2AR down-regulation occurs as a result of not only internalized receptor degradation but also a novel cAMP/PKA/CREB-mediated increase in let-7f, which causes enhanced repression of the beta2AR gene, adrenoreceptor beta2 ( ADRB2) translation and represents ~50% of the net loss of receptors observed after prolonged agonist exposure. Cyclic AMP adrenoceptor beta 2 Homo sapiens