Pub. Date : 2018 Feb 14
PMID : 29381356
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Astaxanthin Induces the Nrf2/HO-1 Antioxidant Pathway in Human Umbilical Vein Endothelial Cells by Generating Trace Amounts of ROS. | astaxanthine | heme oxygenase 1 | Homo sapiens |
| 2 | In addition, astaxanthin increased the mRNA levels of phase II enzymes HO-1 and also promoted GSH-Px enzyme activity. | astaxanthine | heme oxygenase 1 | Homo sapiens |
| 3 | Knockdown of Nrf-2 by small interfering RNA inhibited HO-1 mRNA expression by 60%, indicating that the Nrf-2/ARE signaling pathway is activated by astaxanthin. | astaxanthine | heme oxygenase 1 | Homo sapiens |
| 4 | Our results suggest that astaxanthin activates the Nrf-2/HO-1 antioxidant pathway by generating small amounts of ROS. | astaxanthine | heme oxygenase 1 | Homo sapiens |