Title : A glucose-responsive insulin therapy protects animals against hypoglycemia.

Pub. Date : 2018 Jan 11

PMID : 29321379






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 When the blood glucose level is elevated, as in individuals with diabetes mellitus, MR binding diminishes due to glucose competition, leading to reduced MR-mediated clearance and increased partitioning for IR binding and consequent glucose lowering. Glucose insulin receptor Homo sapiens
2 When the blood glucose level is elevated, as in individuals with diabetes mellitus, MR binding diminishes due to glucose competition, leading to reduced MR-mediated clearance and increased partitioning for IR binding and consequent glucose lowering. Glucose insulin receptor Homo sapiens
3 When the blood glucose level is elevated, as in individuals with diabetes mellitus, MR binding diminishes due to glucose competition, leading to reduced MR-mediated clearance and increased partitioning for IR binding and consequent glucose lowering. Glucose insulin receptor Homo sapiens
4 These studies demonstrate that a glucose-dependent locus of insulin clearance and, hence, insulin action can be achieved by targeting MR and IR concurrently. Glucose insulin receptor Homo sapiens