Title : Hepatic peroxisome proliferator-activated receptor alpha mediates the major metabolic effects of Wy-14643.

Pub. Date : 2018 May

PMID : 29141109






6 Functional Relationships(s)
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1 Hepatic peroxisome proliferator-activated receptor alpha mediates the major metabolic effects of Wy-14643. pirinixic acid peroxisome proliferator activated receptor alpha Mus musculus
2 METHODS: A hepatocyte-specific Ppara knockout mouse line was used to explore the impact of hepatic PPARalpha activity on the systemic response to treatment with the potent PPARalpha agonist Wy-14643. pirinixic acid peroxisome proliferator activated receptor alpha Mus musculus
3 METHODS: A hepatocyte-specific Ppara knockout mouse line was used to explore the impact of hepatic PPARalpha activity on the systemic response to treatment with the potent PPARalpha agonist Wy-14643. pirinixic acid peroxisome proliferator activated receptor alpha Mus musculus
4 Hepatic Ppara disruption abolished the triglyceride lowering effects of Wy-14643, prevented agonist-induced hypophagia, and ablated PPARalpha target gene response in the liver. pirinixic acid peroxisome proliferator activated receptor alpha Mus musculus
5 CONCLUSIONS: These findings indicate that Wy-14643 treatment mainly activates hepatic PPARalpha, and the hypolipidemic and hypophagic effects of Wy-14643 are dependent on PPARalpha activation within hepatocytes. pirinixic acid peroxisome proliferator activated receptor alpha Mus musculus
6 CONCLUSIONS: These findings indicate that Wy-14643 treatment mainly activates hepatic PPARalpha, and the hypolipidemic and hypophagic effects of Wy-14643 are dependent on PPARalpha activation within hepatocytes. pirinixic acid peroxisome proliferator activated receptor alpha Mus musculus