Title : Long-acting β2-adrenoreceptor agonists suppress type 1 interferon expression in human plasmacytoid dendritic cells via epigenetic regulation.

Pub. Date : 2018 Feb

PMID : 28987803






1 Functional Relationships(s)
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1 LABA suppressed TLR7/9-induced type 1 IFNs production, at least partly, via the beta2-adrenoreceptor-cAMP-Epac-Ca2+, IRF-3/IRF-7, the MAPK-p38/ERK pathway, and epigenetic regulation by suppressing histone H3K4 trimethylation through inhibiting the translocation of WDR5 from cytoplasm to nucleus. Cyclic AMP adrenoceptor beta 2 Homo sapiens