Title : Therapeutic Effects of PPARĪ± Agonist on Ocular Neovascularization in Models Recapitulating Neovascular Age-Related Macular Degeneration.

Pub. Date : 2017 Oct 1

PMID : 28980001






7 Functional Relationships(s)
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1 Purpose: This study was designed to evaluate effects of fenofibric acid (Feno-FA), a peroxisome proliferator-activated receptor-alpha (PPARalpha) agonist, on ocular neovascularization (NV) in models recapitulating neovascular age-related macular degeneration (AMD), and to explore whether the effects are PPARalpha dependent. fenofibric acid peroxisome proliferator activated receptor alpha Mus musculus
2 Purpose: This study was designed to evaluate effects of fenofibric acid (Feno-FA), a peroxisome proliferator-activated receptor-alpha (PPARalpha) agonist, on ocular neovascularization (NV) in models recapitulating neovascular age-related macular degeneration (AMD), and to explore whether the effects are PPARalpha dependent. fenofibric acid peroxisome proliferator activated receptor alpha Mus musculus
3 Purpose: This study was designed to evaluate effects of fenofibric acid (Feno-FA), a peroxisome proliferator-activated receptor-alpha (PPARalpha) agonist, on ocular neovascularization (NV) in models recapitulating neovascular age-related macular degeneration (AMD), and to explore whether the effects are PPARalpha dependent. fenofibric acid peroxisome proliferator activated receptor alpha Mus musculus
4 Purpose: This study was designed to evaluate effects of fenofibric acid (Feno-FA), a peroxisome proliferator-activated receptor-alpha (PPARalpha) agonist, on ocular neovascularization (NV) in models recapitulating neovascular age-related macular degeneration (AMD), and to explore whether the effects are PPARalpha dependent. fenofibric acid peroxisome proliferator activated receptor alpha Mus musculus
5 Purpose: This study was designed to evaluate effects of fenofibric acid (Feno-FA), a peroxisome proliferator-activated receptor-alpha (PPARalpha) agonist, on ocular neovascularization (NV) in models recapitulating neovascular age-related macular degeneration (AMD), and to explore whether the effects are PPARalpha dependent. fenofibric acid peroxisome proliferator activated receptor alpha Mus musculus
6 Furthermore, Pparalpha-/- mice developed more severe CNV compared with WT mice, and PPARalpha knockout abolished the beneficial effects of Feno-FA on CNV. fenofibric acid peroxisome proliferator activated receptor alpha Mus musculus
7 Conclusions: Feno-FA has therapeutic effects on ocular NV in models recapitulating neovascular AMD through a PPARalpha-dependent mechanism. fenofibric acid peroxisome proliferator activated receptor alpha Mus musculus