Pub. Date : 2018
PMID : 28971779
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | New Ferrocene Compounds as Selective Cyclooxygenase (COX-2) Inhibitors: Design, Synthesis, Cytotoxicity and Enzyme-inhibitory Activity. | ferrocene | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 2 | CONCLUSION: A novel group of ferrocene compounds, possessing a methyl sulfonyl COX-2 pharmacophore were synthesized to investigate the effect of different substituents on selectivity and potency of COX-2 inhibitory activity and their cytotoxicity effects. | ferrocene | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 3 | CONCLUSION: A novel group of ferrocene compounds, possessing a methyl sulfonyl COX-2 pharmacophore were synthesized to investigate the effect of different substituents on selectivity and potency of COX-2 inhibitory activity and their cytotoxicity effects. | ferrocene | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 4 | This study indicates that 1-ferrocenyl-3-amino carbonyl compounds having ferrocene motif and methyl sulfonyl COX-2 pharmacophore is a suitable scaffold to design COX-2 inhibitors and anti-cancer agents. | ferrocene | prostaglandin-endoperoxide synthase 2 | Homo sapiens |