Pub. Date : 2017 Sep
PMID : 28766689
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we demonstrated that nicotine exerts its anti-inflammatory effect by TIPE2 upregulation and phosphorylated stat3 mediated the inhibition of NF-kappaB activation, which was supported by the following evidence: firstly, both nicotine and TIPE2 inhibit pro-inflammatory cytokine release via NF-kappaB inactivation. | Nicotine | signal transducer and activator of transcription 3 | Homo sapiens |
| 2 | Here, we demonstrated that nicotine exerts its anti-inflammatory effect by TIPE2 upregulation and phosphorylated stat3 mediated the inhibition of NF-kappaB activation, which was supported by the following evidence: firstly, both nicotine and TIPE2 inhibit pro-inflammatory cytokine release via NF-kappaB inactivation. | Nicotine | signal transducer and activator of transcription 3 | Homo sapiens |
| 3 | Moreover, the enhancement of stat3 phosphorylation and decrease of LPS-induced p65 translocation were achieved by nicotine treatment. | Nicotine | signal transducer and activator of transcription 3 | Homo sapiens |
| 4 | Importantly, nicotine treatment augments the interaction of phosphorylated stat3 and p65, indicating that the inhibitory effect of nicotine on NF-kappaB activation was mediated with protein-protein interactions. | Nicotine | signal transducer and activator of transcription 3 | Homo sapiens |
| 5 | Importantly, nicotine treatment augments the interaction of phosphorylated stat3 and p65, indicating that the inhibitory effect of nicotine on NF-kappaB activation was mediated with protein-protein interactions. | Nicotine | signal transducer and activator of transcription 3 | Homo sapiens |
| 6 | Hence, this study revealed that TIPE2 upregulation and stat3 phosphorylation contribute to nicotine-mediated anti-inflammation effect, indicating that TIPE2 and stat3 might be potential molecules for dealing with inflammation-associated diseases. | Nicotine | signal transducer and activator of transcription 3 | Homo sapiens |
| 7 | Hence, this study revealed that TIPE2 upregulation and stat3 phosphorylation contribute to nicotine-mediated anti-inflammation effect, indicating that TIPE2 and stat3 might be potential molecules for dealing with inflammation-associated diseases. | Nicotine | signal transducer and activator of transcription 3 | Homo sapiens |