Title : Nicotine induces TIPE2 upregulation and Stat3 phosphorylation contributes to cholinergic anti-inflammatory effect.

Pub. Date : 2017 Sep

PMID : 28766689






7 Functional Relationships(s)
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1 Here, we demonstrated that nicotine exerts its anti-inflammatory effect by TIPE2 upregulation and phosphorylated stat3 mediated the inhibition of NF-kappaB activation, which was supported by the following evidence: firstly, both nicotine and TIPE2 inhibit pro-inflammatory cytokine release via NF-kappaB inactivation. Nicotine signal transducer and activator of transcription 3 Homo sapiens
2 Here, we demonstrated that nicotine exerts its anti-inflammatory effect by TIPE2 upregulation and phosphorylated stat3 mediated the inhibition of NF-kappaB activation, which was supported by the following evidence: firstly, both nicotine and TIPE2 inhibit pro-inflammatory cytokine release via NF-kappaB inactivation. Nicotine signal transducer and activator of transcription 3 Homo sapiens
3 Moreover, the enhancement of stat3 phosphorylation and decrease of LPS-induced p65 translocation were achieved by nicotine treatment. Nicotine signal transducer and activator of transcription 3 Homo sapiens
4 Importantly, nicotine treatment augments the interaction of phosphorylated stat3 and p65, indicating that the inhibitory effect of nicotine on NF-kappaB activation was mediated with protein-protein interactions. Nicotine signal transducer and activator of transcription 3 Homo sapiens
5 Importantly, nicotine treatment augments the interaction of phosphorylated stat3 and p65, indicating that the inhibitory effect of nicotine on NF-kappaB activation was mediated with protein-protein interactions. Nicotine signal transducer and activator of transcription 3 Homo sapiens
6 Hence, this study revealed that TIPE2 upregulation and stat3 phosphorylation contribute to nicotine-mediated anti-inflammation effect, indicating that TIPE2 and stat3 might be potential molecules for dealing with inflammation-associated diseases. Nicotine signal transducer and activator of transcription 3 Homo sapiens
7 Hence, this study revealed that TIPE2 upregulation and stat3 phosphorylation contribute to nicotine-mediated anti-inflammation effect, indicating that TIPE2 and stat3 might be potential molecules for dealing with inflammation-associated diseases. Nicotine signal transducer and activator of transcription 3 Homo sapiens