Title : The α3β4 nAChR partial agonist AT-1001 attenuates stress-induced reinstatement of nicotine seeking in a rat model of relapse and induces minimal withdrawal in dependent rats.

Pub. Date : 2017 Aug 30

PMID : 28693859






5 Functional Relationships(s)
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1 The alpha3beta4 nAChR partial agonist AT-1001 attenuates stress-induced reinstatement of nicotine seeking in a rat model of relapse and induces minimal withdrawal in dependent rats. Nicotine cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus
2 Recent genetic and preclinical studies have highlighted the involvement of the alpha3, beta4, and alpha5 nicotinic acetylcholine receptor (nAChR) subunits and the alpha3beta4 nAChR subtype in nicotine dependence and withdrawal. Nicotine cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus
3 We previously reported that the alpha3beta4 nAChR partial agonist AT-1001 selectively decreases nicotine self-administration in rats without affecting food responding. Nicotine cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus
4 Our data suggest that alpha3beta4 nAChR-targeted compounds may be a promising approach for nicotine addiction treatment because they can not only block nicotine"s reinforcing effects, but also decrease motivation to relapse without producing significant withdrawal effects. Nicotine cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus
5 Our data suggest that alpha3beta4 nAChR-targeted compounds may be a promising approach for nicotine addiction treatment because they can not only block nicotine"s reinforcing effects, but also decrease motivation to relapse without producing significant withdrawal effects. Nicotine cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus