Title : Aerosolized liposomes with dipalmitoyl phosphatidylcholine enhance pulmonary absorption of encapsulated insulin compared with co-administered insulin.

Pub. Date : 2017 Nov

PMID : 28689439






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1 Aerosolized liposomes with dipalmitoyl phosphatidylcholine enhance pulmonary absorption of encapsulated insulin compared with co-administered insulin. 1,2-Dipalmitoylphosphatidylcholine insulin Homo sapiens
2 OBJECTIVE: We have previously shown that aerosolized liposomes with dipalmitoyl phosphatidylcholine (DPPC) enhance the pulmonary absorption of encapsulated insulin. 1,2-Dipalmitoylphosphatidylcholine insulin Homo sapiens
3 OBJECTIVE: We have previously shown that aerosolized liposomes with dipalmitoyl phosphatidylcholine (DPPC) enhance the pulmonary absorption of encapsulated insulin. 1,2-Dipalmitoylphosphatidylcholine insulin Homo sapiens
4 RESULTS: DPPC liposomes enhanced the pulmonary absorption of unencapsulated free insulin; however, the enhancing effect was lower than that of the DPPC liposomes encapsulating insulin. 1,2-Dipalmitoylphosphatidylcholine insulin Homo sapiens
5 The mechanism of the pulmonary absorption of unencapsulated free insulin by DPPC liposomes involved the opening of epithelial cell space in alveolar mucosa, and not mucosal cell damage, similar to that of the DPPC liposomes encapsulating insulin. 1,2-Dipalmitoylphosphatidylcholine insulin Homo sapiens
6 The mechanism of the pulmonary absorption of unencapsulated free insulin by DPPC liposomes involved the opening of epithelial cell space in alveolar mucosa, and not mucosal cell damage, similar to that of the DPPC liposomes encapsulating insulin. 1,2-Dipalmitoylphosphatidylcholine insulin Homo sapiens
7 The mechanism of the pulmonary absorption of unencapsulated free insulin by DPPC liposomes involved the opening of epithelial cell space in alveolar mucosa, and not mucosal cell damage, similar to that of the DPPC liposomes encapsulating insulin. 1,2-Dipalmitoylphosphatidylcholine insulin Homo sapiens
8 These findings suggest that, although unencapsulated free insulin spreads throughout the alveolar mucus layer, the concentration of insulin released near the absorption surface is increased by the encapsulation of insulin into DPPC liposomes and the absorption efficiency is also increased. 1,2-Dipalmitoylphosphatidylcholine insulin Homo sapiens
9 These findings suggest that, although unencapsulated free insulin spreads throughout the alveolar mucus layer, the concentration of insulin released near the absorption surface is increased by the encapsulation of insulin into DPPC liposomes and the absorption efficiency is also increased. 1,2-Dipalmitoylphosphatidylcholine insulin Homo sapiens
10 CONCLUSION: We revealed that the encapsulation of insulin into DPPC liposomes is more effective for pulmonary insulin absorption than co-administration of DPPC liposomes and unencapsulated free insulin. 1,2-Dipalmitoylphosphatidylcholine insulin Homo sapiens
11 CONCLUSION: We revealed that the encapsulation of insulin into DPPC liposomes is more effective for pulmonary insulin absorption than co-administration of DPPC liposomes and unencapsulated free insulin. 1,2-Dipalmitoylphosphatidylcholine insulin Homo sapiens