Title : Induction of sirtuin-1 signaling by resveratrol induces human chondrosarcoma cell apoptosis and exhibits antitumor activity.

Pub. Date : 2017 Jun 9

PMID : 28600541






3 Functional Relationships(s)
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Protein Name
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1 Resveratrol induced-apoptosis involved a caspase-3-mediated mechanism. Resveratrol caspase 3 Homo sapiens
2 Both siRNA-SIRT1 transfection and MS-275 significantly inhibited the resveratrol-induced caspase-3 cleavage and activity in human chondrosarcoma cells. Resveratrol caspase 3 Homo sapiens
3 Moreover, in vivo chondrosarcoma xenograft study revealed a dramatic reduction in tumor volume and the increased SIRT1 and cleaved caspase-3 expressions in tumors by resveratrol treatment. Resveratrol caspase 3 Homo sapiens