Pub. Date : 2017 May 17
PMID : 28515436
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nimbolide upregulates RECK by targeting miR-21 and HIF-1alpha in cell lines and in a hamster oral carcinogenesis model. | nimbolide | reversion inducing cysteine rich protein with kazal motifs | Homo sapiens |
| 2 | We also report the chemotherapeutic effect of nimbolide, a limonoid from the neem tree (Azadirachta indica) based on the upregulation of RECK as well as modulation of the expression of key molecules involved in invasion and angiogenesis. | nimbolide | reversion inducing cysteine rich protein with kazal motifs | Homo sapiens |
| 3 | We demonstrate that nimbolide upregulates RECK by targeting miR-21, and HIF-1alpha resulting in reduced MMP activity and blockade of VEGF and Notch signalling. | nimbolide | reversion inducing cysteine rich protein with kazal motifs | Homo sapiens |
| 4 | Additionally, we demonstrate that nimbolide upregulates RECK expression via downregulation of HIF-1alpha and miR-21 by overexpression and knockdown experiments in SCC4 and EAhy926 cell lines. | nimbolide | reversion inducing cysteine rich protein with kazal motifs | Homo sapiens |
| 5 | Taken together, these findings provide compelling evidence that targeting RECK, a keystone protein that regulates mediators of invasion and angiogenesis with phytochemicals such as nimbolide may be a robust therapeutic approach to prevent oral cancer progression. | nimbolide | reversion inducing cysteine rich protein with kazal motifs | Homo sapiens |