Title : A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling.

Pub. Date : 2017 Apr 18

PMID : 28416805






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Interestingly, Barbadin fully blocks V2R-stimulated ERK1/2 activation and blunts cAMP accumulation promoted by both V2R and beta2AR, supporting the concept of beta-arrestin/AP2-dependent signalling for both G protein-dependent and -independent pathways. Cyclic AMP adrenoceptor beta 2 Homo sapiens