Title : Overexpression of matrix metalloproteinase-9 (MMP-9) rescues insulin-mediated impairment in the 5XFAD model of Alzheimer's disease.

Pub. Date : 2017 Apr 6

PMID : 28386117






1 Functional Relationships(s)
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1 In 5XFAD/TgMMP-9 samples, the insulin survival pathway was rescued through enhanced activation by phosphorylation of IRS1 at Tyrosine 465 (pIRS1-Tyr465), downstream increased phosphorylation of Akt and GSK-3beta, and decreased phosphorylation of JNK kinase. Tyrosine insulin receptor substrate 1 Mus musculus