Title : An important intestinal transporter that regulates the enterohepatic circulation of bile acids and cholesterol homeostasis: The apical sodium-dependent bile acid transporter (SLC10A2/ASBT).

Pub. Date : 2017 Oct

PMID : 28336180






6 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 An important intestinal transporter that regulates the enterohepatic circulation of bile acids and cholesterol homeostasis: The apical sodium-dependent bile acid transporter (SLC10A2/ASBT). Cholesterol solute carrier family 10 member 2 Homo sapiens
2 An important intestinal transporter that regulates the enterohepatic circulation of bile acids and cholesterol homeostasis: The apical sodium-dependent bile acid transporter (SLC10A2/ASBT). Cholesterol solute carrier family 10 member 2 Homo sapiens
3 Previous studies revealed that regulation of the ASBT involves BAs and cholesterol. Cholesterol solute carrier family 10 member 2 Homo sapiens
4 In addition, abnormal ASBT expression and function might lead to some diseases associated with disorders in the enterohepatic circulation of BAs and cholesterol homeostasis, such as diarrhoea and gallstones. Cholesterol solute carrier family 10 member 2 Homo sapiens
5 However, decreasing cholesterol or BAs by partly inhibiting ASBT-mediated transport might be used for treatments of hypercholesterolemia, cholestasis and diabetes. Cholesterol solute carrier family 10 member 2 Homo sapiens
6 This review mainly discusses the regulation of the ASBT by BAs and cholesterol and its relevance to diseases and treatment. Cholesterol solute carrier family 10 member 2 Homo sapiens