Title : Distinct transcriptome profiles of Gag-specific CD8+ T cells temporally correlated with the protection elicited by SIVĪ”nef live attenuated vaccine.

Pub. Date : 2017

PMID : 28333940






1 Functional Relationships(s)
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1 At 20 WPV, the most significant transcriptional changes of Gag-specific CD8+ T cells were genes involved in TCR signaling, differentiation and maturation toward central memory cells, with increased expression of CCR7, TCRalpha, TCRbeta, CD28 and decreased expression of CTLA-4, IFN-gamma, RANTES, granzyme A and B. Glycosaminoglycans C-C motif chemokine ligand 5 Homo sapiens