Pub. Date : 2017
PMID : 28289409
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Similar increases in gene expression of NLRP3, apoptosis associated speck like protein (ASC) and pro-IL-1beta were induced by multiple low doses of streptozotocin (STZ) in C57BL/6 mice. | Streptozocin | interleukin 1 beta | Mus musculus |
| 2 | Similar increases in gene expression of NLRP3, apoptosis associated speck like protein (ASC) and pro-IL-1beta were induced by multiple low doses of streptozotocin (STZ) in C57BL/6 mice. | Streptozocin | interleukin 1 beta | Mus musculus |
| 3 | Overall, our results demonstrate that mDNA-mediated NLRP3 activation triggers caspase-1-dependent IL-1beta production and contributes to pathogenic cellular responses during the development of STZ-induced T1D. | Streptozocin | interleukin 1 beta | Mus musculus |