Title : Localization of the gate and selectivity filter of the full-length P2X7 receptor.

Pub. Date : 2017 Mar 14

PMID : 28235784






1 Functional Relationships(s)
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1 Here, we studied the accessibility of single cysteines substituted along the pre-TM2 and TM2 helix (residues 327-357) of the P2X7R using as readouts (i) the covalent maleimide fluorescence accessibility of the surface-bound P2X7R and (ii) covalent modulation of macroscopic and single-channel currents using extracellularly and intracellularly applied methanethiosulfonate (MTS) reagents. methanethiosulfonate purinergic receptor P2X 7 Homo sapiens