Title : Oxidative Stress-Related Genetic Variants May Modify Associations of Phthalate Exposures with Asthma.

Pub. Date : 2017 Feb 8

PMID : 28208751






5 Functional Relationships(s)
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1 Children with the GSTP1 (rs1695) AA and SOD2 (rs5746136) TT genotypes had higher MEHHP levels as compared to GG and CC types, respectively. mono(2-ethyl-5-hydroxyhexyl) phthalate superoxide dismutase 2 Homo sapiens
2 As MEHHP concentrations were dependent on GSTP1 and SOD2, but the assessment of interaction requires independent variables, we estimated MEHHP residuals and assessed their interaction, showing that the OR for SOD2 TT was further elevated to 3.32 (1.75-6.32) when the residuals of MEHHP were high. mono(2-ethyl-5-hydroxyhexyl) phthalate superoxide dismutase 2 Homo sapiens
3 As MEHHP concentrations were dependent on GSTP1 and SOD2, but the assessment of interaction requires independent variables, we estimated MEHHP residuals and assessed their interaction, showing that the OR for SOD2 TT was further elevated to 3.32 (1.75-6.32) when the residuals of MEHHP were high. mono(2-ethyl-5-hydroxyhexyl) phthalate superoxide dismutase 2 Homo sapiens
4 As MEHHP concentrations were dependent on GSTP1 and SOD2, but the assessment of interaction requires independent variables, we estimated MEHHP residuals and assessed their interaction, showing that the OR for SOD2 TT was further elevated to 3.32 (1.75-6.32) when the residuals of MEHHP were high. mono(2-ethyl-5-hydroxyhexyl) phthalate superoxide dismutase 2 Homo sapiens
5 As MEHHP concentrations were dependent on GSTP1 and SOD2, but the assessment of interaction requires independent variables, we estimated MEHHP residuals and assessed their interaction, showing that the OR for SOD2 TT was further elevated to 3.32 (1.75-6.32) when the residuals of MEHHP were high. mono(2-ethyl-5-hydroxyhexyl) phthalate superoxide dismutase 2 Homo sapiens