Title : Activation of PPARĪ³ by endogenous prostaglandin J2 mediates the antileukemic effect of selenium in murine leukemia.

Pub. Date : 2017 Mar 30

PMID : 28115365






1 Functional Relationships(s)
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1 This effect was mediated by an increase in 15-prostaglandin dehydrogenase (15-Pgdh) activity, which oxidizes and inactivates Delta12-PGJ2 and 15d-PGJ2 In contrast, treatment with the PPARgamma agonist pioglitazone mimicked selenium supplementation. 15-deoxy-delta(12,14)-prostaglandin J2 peroxisome proliferator activated receptor gamma Mus musculus