Title : Zinc deficiency affects the STAT1/3 signaling pathways in part through redox-mediated mechanisms.

Pub. Date : 2017 Apr

PMID : 28086195






2 Functional Relationships(s)
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1 In zinc depleted IMR-32 cells, the low tyrosine phosphorylation of STAT1, but not that of STAT3, recovered upon incubation with LA. Tyrosine signal transducer and activator of transcription 1 Homo sapiens
2 In summary, the redox-dependent tyrosine phosphorylation, and oxidant-mediated disruption of the cytoskeleton are involved in the deleterious effects of zinc deficit on STAT1 and STAT3 activation and nuclear translocation. Tyrosine signal transducer and activator of transcription 1 Homo sapiens