Title : Influence of nicotine on doxorubicin and cyclophosphamide combination treatment-induced spatial cognitive impairment and anxiety-like behavior in rats.

Pub. Date : 2017 Apr

PMID : 28064347






4 Functional Relationships(s)
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1 This effect of nicotine was blocked by methyllycaconitine, a selective alpha7 nicotinic acetylcholine receptor (nAChR) antagonist, and dihydro-beta-erythroidine, a selective alpha4beta2 nAChR antagonist. Nicotine cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus
2 This effect of nicotine was blocked by methyllycaconitine, a selective alpha7 nicotinic acetylcholine receptor (nAChR) antagonist, and dihydro-beta-erythroidine, a selective alpha4beta2 nAChR antagonist. Nicotine cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus
3 These results suggest that nicotine inhibits doxorubicin and cyclophosphamide-induced cognitive impairment via alpha7 nAChR and alpha4beta2 nAChR, and also enhances hippocampal neurogenesis. Nicotine cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus
4 These results suggest that nicotine inhibits doxorubicin and cyclophosphamide-induced cognitive impairment via alpha7 nAChR and alpha4beta2 nAChR, and also enhances hippocampal neurogenesis. Nicotine cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus