Title : Minimally Toxic Dose of Lipopolysaccharide and α-Synuclein Oligomer Elicit Synergistic Dopaminergic Neurodegeneration: Role and Mechanism of Microglial NOX2 Activation.

Pub. Date : 2018 Jan

PMID : 27975175

1 Functional Relationships(s)
Compound Name
Protein Name
1 NOX2-/- mice are more resistant to synergistic neurotoxicity than NOX2+/+mice in vivo and in vitro, and NOX2 inhibitor protects against synergistic neurotoxicity through decreasing microglial superoxide production, illustrating a critical role of microglial NOX2. Superoxides cytochrome b-245, beta polypeptide Mus musculus