Title : NADPH oxidase gp91phox contributes to RANKL-induced osteoclast differentiation by upregulating NFATc1.

Pub. Date : 2016 Nov 29

PMID : 27897222






3 Functional Relationships(s)
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Protein Name
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1 Gp91phox, a plasma membrane subunit of NADPH oxidase (Nox), is constitutively expressed in BMMs and plays a major role in superoxide anion production. Superoxides cytochrome b-245, beta polypeptide Mus musculus
2 Treating wild-type BMMs with antioxidants and superoxide inhibitors resulted in a differentiation defect resembling the phenotype of gp91phox-/- BMMs. Superoxides cytochrome b-245, beta polypeptide Mus musculus
3 Therefore, our results demonstrate that gp91phox-derived superoxide is important for promoting efficient osteoclast differentiation by inducing NFATc1 as a downstream signaling mediator of RANK. Superoxides cytochrome b-245, beta polypeptide Mus musculus