Title : Butein inhibits IL-1β-induced inflammatory response in human osteoarthritis chondrocytes and slows the progression of osteoarthritis in mice.

Pub. Date : 2017 Jan

PMID : 27863298






1 Functional Relationships(s)
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1 We found that butein significantly inhibited the IL-1beta-induced production of NO and PGE2, expression of COX-2, iNOS, TNF-alpha, IL-6 and MMP-13, degradation of COL-2 and SOX-9 at mRNA and protein levels as well as MMP-1, MMP-3, ADAMTS-4 and ADAMTS-5 gene expression. Dinoprostone interleukin 1 beta Homo sapiens