Title : An HIV-1 Env-Antibody Complex Focuses Antibody Responses to Conserved Neutralizing Epitopes.

Pub. Date : 2016 Nov 15

PMID : 27815444






1 Functional Relationships(s)
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1 Comparison of the routes of binding used by the CD4bs-directed bNAbs from patients and the vaccine-elicited CD4bs-directed mAbs indicates that the latter fail to neutralize primary virus isolates because they approach the Env spike with a vertical angle and contact the specific surface residues occluded in the native spike, including the bridging sheet on gp120. bnabs inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens