Title : Naturally Occurring Autoantibodies against Tau Protein Are Reduced in Parkinson's Disease Dementia.

Pub. Date : 2016

PMID : 27802290






7 Functional Relationships(s)
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1 MATERIALS AND METHODS: We established three different ELISAs to quantify the nAbs-tau, nAbs-alphaS, and nAbs-Abeta levels and avidity towards their specific antigen in serum samples of 18 non-demented (PDND) and 18 demented PD patients (PDD), which were taken from an ongoing multi-center cohort study (DEMPARK/LANDSCAPE). nabs microtubule associated protein tau Homo sapiens
2 RESULTS: PDD patients had significantly decreased nAbs-tau serum levels compared to PDND patients (p = 0.007), whereas the serum titers of nAbs-alphaS and nAbs-Abeta were unchanged. nabs microtubule associated protein tau Homo sapiens
3 However, within both patient groups, nAbs-tau showed lowest avidity to their antigen, followed by nAbs-alphaS, and nAbs-Abeta. nabs microtubule associated protein tau Homo sapiens
4 CONCLUSION: We detected a significantly decreased nAbs-tau serum level in PDD patients, indicating a potential linkage between nAbs-tau serum titer and cognitive deficits in PD. nabs microtubule associated protein tau Homo sapiens
5 CONCLUSION: We detected a significantly decreased nAbs-tau serum level in PDD patients, indicating a potential linkage between nAbs-tau serum titer and cognitive deficits in PD. nabs microtubule associated protein tau Homo sapiens
6 CONCLUSION: We detected a significantly decreased nAbs-tau serum level in PDD patients, indicating a potential linkage between nAbs-tau serum titer and cognitive deficits in PD. nabs microtubule associated protein tau Homo sapiens
7 CONCLUSION: We detected a significantly decreased nAbs-tau serum level in PDD patients, indicating a potential linkage between nAbs-tau serum titer and cognitive deficits in PD. nabs microtubule associated protein tau Homo sapiens