Title : Disruption of calcium homeostasis by cardiac-specific over-expression of PPAR-γ in mice: A role in ventricular arrhythmia.

Pub. Date : 2016 Dec 15

PMID : 27746188






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1 Disruption of calcium homeostasis by cardiac-specific over-expression of PPAR-gamma in mice: A role in ventricular arrhythmia. Calcium peroxisome proliferator activated receptor gamma Mus musculus
2 Besides, we found the calcium regulatory proteins expression were higher in the TG-PPAR-gamma mice, PPAR-gamma overexpressing human cardiomyocyte line AC16 cell and PPAR-gamma agonist-treated primary cardiomyocytes than the control group respectively. Calcium peroxisome proliferator activated receptor gamma Mus musculus
3 Besides, we found the calcium regulatory proteins expression were higher in the TG-PPAR-gamma mice, PPAR-gamma overexpressing human cardiomyocyte line AC16 cell and PPAR-gamma agonist-treated primary cardiomyocytes than the control group respectively. Calcium peroxisome proliferator activated receptor gamma Mus musculus
4 In addition, an increase of intracellular calcium levels and CaMKII delta expression in PPAR-gamma overexpression and PPAR-gamma activation group. Calcium peroxisome proliferator activated receptor gamma Mus musculus
5 In addition, an increase of intracellular calcium levels and CaMKII delta expression in PPAR-gamma overexpression and PPAR-gamma activation group. Calcium peroxisome proliferator activated receptor gamma Mus musculus
6 SIGNIFICANCE: PPAR-gamma over-expression perturbs the intracellular calcium homeostasis in cardiomyocytes which contribute to the ventricular arrhythmias and cardiac sudden death in TG-PPAR-gamma mice. Calcium peroxisome proliferator activated receptor gamma Mus musculus
7 SIGNIFICANCE: PPAR-gamma over-expression perturbs the intracellular calcium homeostasis in cardiomyocytes which contribute to the ventricular arrhythmias and cardiac sudden death in TG-PPAR-gamma mice. Calcium peroxisome proliferator activated receptor gamma Mus musculus