Title : Nicotine protects against DSS colitis through regulating microRNA-124 and STAT3.

Pub. Date : 2017 Feb

PMID : 27709266






8 Functional Relationships(s)
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1 Nicotine protects against DSS colitis through regulating microRNA-124 and STAT3. Nicotine signal transducer and activator of transcription 3 Homo sapiens
2 Further analysis indicated that nicotine inhibited STAT3 activation in vivo and in IL-6 treated Caco-2 cells and Jurkat human T lymphocytes, in which miR-124 knockdown led to increased activation of STAT3. Nicotine signal transducer and activator of transcription 3 Homo sapiens
3 Further analysis indicated that nicotine inhibited STAT3 activation in vivo and in IL-6 treated Caco-2 cells and Jurkat human T lymphocytes, in which miR-124 knockdown led to increased activation of STAT3. Nicotine signal transducer and activator of transcription 3 Homo sapiens
4 Blocking STAT3 activity alone is beneficial for DSS colitis and also abolished nicotine"s protective effect in this model. Nicotine signal transducer and activator of transcription 3 Homo sapiens
5 These data indicate that nicotine exerts its protective action in UC through inducing miR-124 and inhibiting STAT3, and suggest that the miR-124/STAT3 system is a potential target for the therapeutic intervention of UC. Nicotine signal transducer and activator of transcription 3 Homo sapiens
6 These data indicate that nicotine exerts its protective action in UC through inducing miR-124 and inhibiting STAT3, and suggest that the miR-124/STAT3 system is a potential target for the therapeutic intervention of UC. Nicotine signal transducer and activator of transcription 3 Homo sapiens
7 MiR-124 mediates the inhibitory role of nicotine on STAT3/p-STAT3. Nicotine signal transducer and activator of transcription 3 Homo sapiens
8 MiR-124 mediates the inhibitory role of nicotine on STAT3/p-STAT3. Nicotine signal transducer and activator of transcription 3 Homo sapiens