Title : Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence.

Pub. Date : 2016 Nov 11

PMID : 27687728






1 Functional Relationships(s)
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1 We found that the H684R substitution within human Abeta, which replaces the histidine in the human protein with the arginine found at the corresponding position in mouse, facilitated beta" cleavage irrespective of the species origin of BACE1, thereby significantly increasing the level of Abeta(11-XX) and decreasing the level of Abeta(1-XX). Histidine amyloid beta precursor protein Homo sapiens