Title : Resveratrol inhibits steroidogenesis in human fetal adrenocortical cells at the end of first trimester.

Pub. Date : 2017 Feb

PMID : 27561679






2 Functional Relationships(s)
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1 We observed that resveratrol significantly suppressed synthesis of dehydroepiandrosterone (DHEA), androstenedione and 11-deoxicortisol by ACTH-activated and unstimulated HFAC, which was associated with inhibition of the activities and expression of cytochromes 17alpha-hydroxylase/17,20 lyase (CYP17) and 21-hydroxylase (CYP21) in these fetal adrenocortical cells. Dehydroepiandrosterone proopiomelanocortin Homo sapiens
2 We observed that resveratrol significantly suppressed synthesis of dehydroepiandrosterone (DHEA), androstenedione and 11-deoxicortisol by ACTH-activated and unstimulated HFAC, which was associated with inhibition of the activities and expression of cytochromes 17alpha-hydroxylase/17,20 lyase (CYP17) and 21-hydroxylase (CYP21) in these fetal adrenocortical cells. Dehydroepiandrosterone proopiomelanocortin Homo sapiens