Title : Heme-Regulated eIF2α Kinase Modulates Hepatic FGF21 and Is Activated by PPARβ/δ Deficiency.

Pub. Date : 2016 Oct

PMID : 27486236






1 Functional Relationships(s)
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1 Of note, increased Fgf21 expression in mice fed a high-fat diet or hepatocytes exposed to palmitate was accompanied by reduced PPARbeta/delta and activation of the HRI-eIF2alpha-ATF4 pathway. Palmitates peroxisome proliferator activator receptor delta Mus musculus