Title : The EP3 receptor regulates water excretion in response to high salt intake.

Pub. Date : 2016 Oct 1

PMID : 27465993






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In contrast, the highly selective EP3 receptor antagonist L-798106 (100 mug kg-1 day-1), which increased COX-2 expression and renal PGE2 production, increased urine volume in rats given 1% NaCl. Dinoprostone prostaglandin E receptor 3 Rattus norvegicus
2 Thus, although acute activation of EP3 by PGE2 in the TAL and collecting duct inhibits the Na-K-2Cl cotransporter and AQP2 activity, respectively, chronic activation of EP3 in vivo limits the extent of COX-2-derived PGE2 synthesis, thereby mitigating the inhibitory effects of PGE2 on these transporters and decreasing urine volume. Dinoprostone prostaglandin E receptor 3 Rattus norvegicus
3 Thus, although acute activation of EP3 by PGE2 in the TAL and collecting duct inhibits the Na-K-2Cl cotransporter and AQP2 activity, respectively, chronic activation of EP3 in vivo limits the extent of COX-2-derived PGE2 synthesis, thereby mitigating the inhibitory effects of PGE2 on these transporters and decreasing urine volume. Dinoprostone prostaglandin E receptor 3 Rattus norvegicus
4 Thus, although acute activation of EP3 by PGE2 in the TAL and collecting duct inhibits the Na-K-2Cl cotransporter and AQP2 activity, respectively, chronic activation of EP3 in vivo limits the extent of COX-2-derived PGE2 synthesis, thereby mitigating the inhibitory effects of PGE2 on these transporters and decreasing urine volume. Dinoprostone prostaglandin E receptor 3 Rattus norvegicus