Title : Nandinine, a Derivative of Berberine, Inhibits Inflammation and Reduces Insulin Resistance in Adipocytes via Regulation of AMP-Kinase Activity.

Pub. Date : 2017 Feb

PMID : 27462872






1 Functional Relationships(s)
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1 Furthermore, both berberine and nandinine inhibited serine phosphorylation of insulin receptor substrate-1 induced by IkappaB kinase beta and increased tyrosine phosphorylation of insulin receptor substrate-1 to activate the PI3K/Akt pathway, which finally led to insulin-mediated glucose uptake. Tyrosine insulin receptor substrate 1 Mus musculus