Title : WY14643 Attenuates the Scopolamine-Induced Memory Impairments in Mice.

Pub. Date : 2016 Nov

PMID : 27422264






4 Functional Relationships(s)
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1 WY14643 is a selective agonist of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) with neuroprotective and neurotrophic effects. pirinixic acid peroxisome proliferator activated receptor alpha Mus musculus
2 WY14643 is a selective agonist of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) with neuroprotective and neurotrophic effects. pirinixic acid peroxisome proliferator activated receptor alpha Mus musculus
3 The usage of both PPAR-alpha inhibitor GW6471 and BDNF system inhibitor K252a fully prevented the memory-enhancing effects of WY14643. pirinixic acid peroxisome proliferator activated receptor alpha Mus musculus
4 Therefore, these findings suggest that WY14643 could improve the scopolamine-induced memory impairments, and these effects are mediated by the activation of PPAR-alpha and BDNF system, thereby exhibiting a cognition-enhancing potential. pirinixic acid peroxisome proliferator activated receptor alpha Mus musculus