Pub. Date : 2017 Jan
PMID : 27404795
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Histone deacetylase inhibitor vorinostat (SAHA, MK0683) perturb miR-9-MCPIP1 axis to block IL-1beta-induced IL-6 expression in human OA chondrocytes. | Vorinostat | interleukin 6 | Homo sapiens |
| 2 | Histone deacetylase inhibitor vorinostat (SAHA, MK0683) perturb miR-9-MCPIP1 axis to block IL-1beta-induced IL-6 expression in human OA chondrocytes. | Vorinostat | interleukin 6 | Homo sapiens |
| 3 | Histone deacetylase inhibitor vorinostat (SAHA, MK0683) perturb miR-9-MCPIP1 axis to block IL-1beta-induced IL-6 expression in human OA chondrocytes. | Vorinostat | interleukin 6 | Homo sapiens |
| 4 | Vorinostat (SAHA) inhibits the IL-6 expression in OA chondrocytes. | Vorinostat | interleukin 6 | Homo sapiens |
| 5 | Vorinostat (SAHA) inhibits the IL-6 expression in OA chondrocytes. | Vorinostat | interleukin 6 | Homo sapiens |
| 6 | We investigated whether SAHA suppresses the expression of IL-6 by perturbing the miR-9-MCPIP1 axis in OA chondrocytes under pathological conditions. | Vorinostat | interleukin 6 | Homo sapiens |
| 7 | CONCLUSIONS: Taken together our data indicate that SAHA-mediated suppression of the IL-6 expression is achieved through increased recruitment of CEBPalpha to the MCPIP1 promoter and by relieving the miR-9-mediated inhibition of MCPIP1 expression in OA chondrocytes. | Vorinostat | interleukin 6 | Homo sapiens |