Title : Protein kinase A can block EphA2 receptor-mediated cell repulsion by increasing EphA2 S897 phosphorylation.

Pub. Date : 2016 Sep 1

PMID : 27385333






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Surprisingly, most hits from a screened collection of pharmacologically active compounds are agents that elevate intracellular cAMP by activating G protein-coupled receptors such as the beta2-adrenoceptor. Cyclic AMP adrenoceptor beta 2 Homo sapiens
2 Our findings reveal a novel paradigm in EphA2 function involving the interplay of canonical and noncanonical signaling and highlight the ability of the beta2-adrenoceptor/cAMP/PKA axis to rewire EphA2 signaling in a subset of cancer cells. Cyclic AMP adrenoceptor beta 2 Homo sapiens