Pub. Date : 2016 Sep 28
PMID : 27322737
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, our study showed that nafamostat mesilate abrogated the constitutive NF-kappaB activation in CRC cells, which is mediated through inhibition of phosphorylation of IkappaBalpha and nuclear translocation of p65. | nafamostat | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Furthermore, nafamostat mesilate could reverse oxaliplatin induced NF-kappaB and Erk activation in CRC cells, and enhance the sensitivity of CRC cells to oxaliplatin. | nafamostat | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Overall, our data suggest that nafamostat mesilate, a relatively non-toxic drug that targets NF-kappaB and Erk, may, in combination with oxaliplatin, represent a novel therapeutic strategy for CRC treatment. | nafamostat | nuclear factor kappa B subunit 1 | Homo sapiens |