Title : Inhibition of the NF-κB pathway by nafamostat mesilate suppresses colorectal cancer growth and metastasis.

Pub. Date : 2016 Sep 28

PMID : 27322737






3 Functional Relationships(s)
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1 Here, our study showed that nafamostat mesilate abrogated the constitutive NF-kappaB activation in CRC cells, which is mediated through inhibition of phosphorylation of IkappaBalpha and nuclear translocation of p65. nafamostat nuclear factor kappa B subunit 1 Homo sapiens
2 Furthermore, nafamostat mesilate could reverse oxaliplatin induced NF-kappaB and Erk activation in CRC cells, and enhance the sensitivity of CRC cells to oxaliplatin. nafamostat nuclear factor kappa B subunit 1 Homo sapiens
3 Overall, our data suggest that nafamostat mesilate, a relatively non-toxic drug that targets NF-kappaB and Erk, may, in combination with oxaliplatin, represent a novel therapeutic strategy for CRC treatment. nafamostat nuclear factor kappa B subunit 1 Homo sapiens