Title : Shifting Fitness and Epistatic Landscapes Reflect Trade-offs along an Evolutionary Pathway.

Pub. Date : 2016 Jul 3

PMID : 27173379






1 Functional Relationships(s)
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1 We measured the effect on ampicillin resistance of ~12,500 unique single amino acid mutants of the TEM-1, TEM-17, TEM-19, and TEM-15 beta-lactamase alleles, which constitute an adaptive path in the evolution of cefotaxime resistance. Cefotaxime CD248 molecule Homo sapiens