Title : Targeting the AKT pathway: Repositioning HIV protease inhibitors as radiosensitizers.

Pub. Date : 2016 Feb

PMID : 27121513






1 Functional Relationships(s)
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1 This review describes the mechanisms by which PI3-K/AKT pathway causes radioresistance and the role of HIV protease inhibitors especially nelfinavir as a potential candidate drug to target the AKT pathway for overcoming radioresistance and its use in various clinical trials for different malignancies. Nelfinavir AKT serine/threonine kinase 1 Rattus norvegicus