Title : Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3.

Pub. Date : 2016 May 3

PMID : 27091995






4 Functional Relationships(s)
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1 Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3. Glycosaminoglycans C-C motif chemokine ligand 5 Homo sapiens
2 However, this motif is partially buried when CCL3, CCL4, and CCL5 are oligomerized; thus, the mechanism by which GAG binds these chemokine oligomers has been elusive. Glycosaminoglycans C-C motif chemokine ligand 5 Homo sapiens
3 Our structures of GAG-bound CCL5 and CCL3 oligomers reveal that these chemokine oligomers have distinct GAG-binding mechanisms. Glycosaminoglycans C-C motif chemokine ligand 5 Homo sapiens
4 Our structures of GAG-bound CCL5 and CCL3 oligomers reveal that these chemokine oligomers have distinct GAG-binding mechanisms. Glycosaminoglycans C-C motif chemokine ligand 5 Homo sapiens