Title : Crystal Structure of an Ammonia-Permeable Aquaporin.

Pub. Date : 2016 Mar

PMID : 27028365






2 Functional Relationships(s)
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1 Here, we report the structure determined at 1.18 A resolution from twinned crystals of Arabidopsis thaliana aquaporin AtTIP2;1 and confirm water and ammonia permeability of the purified protein reconstituted in proteoliposomes as further substantiated by molecular dynamics simulations. Water delta tonoplast integral protein Arabidopsis thaliana
2 By mutational studies, we show that the identified determinants in the extended selectivity filter region are sufficient to convert a strictly water-specific human aquaporin into an AtTIP2;1-like ammonia channel. Water delta tonoplast integral protein Arabidopsis thaliana