Title : Protective LRRK2 R1398H Variant Enhances GTPase and Wnt Signaling Activity.

Pub. Date : 2016

PMID : 27013965






1 Functional Relationships(s)
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1 LRRK2 R1398H GTPase domain dimerization and GTP hydrolysis were increased whereas GTP binding was reduced, leading to a decrease in active GTP-bound LRRK2. Guanosine Triphosphate leucine rich repeat kinase 2 Homo sapiens