Title : Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone.

Pub. Date : 2016 Apr 29

PMID : 26989199






1 Functional Relationships(s)
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1 We show that ABHD2 is highly expressed in spermatozoa, binds progesterone, and acts as a progesterone-dependent lipid hydrolase by depleting the endocannabinoid 2-arachidonoylglycerol (2AG) from plasma membrane. glyceryl 2-arachidonate abhydrolase domain containing 2, acylglycerol lipase Homo sapiens