Title : Prostaglandin E₂ possesses different potencies in inducing Vascular Endothelial Growth Factor and Interleukin-8 production in COPD human lung fibroblasts.

Pub. Date : 2016 Mar

PMID : 26926362






5 Functional Relationships(s)
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1 Prostaglandin E2 possesses different potencies in inducing Vascular Endothelial Growth Factor and Interleukin-8 production in COPD human lung fibroblasts. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens
2 We studied the role of PGE2, its biosynthetic enzymes and its receptors, in regulating the functions of lung fibroblasts through the production of Vascular Endothelial Growth Factor (VEGF) and Interleukin-8 (IL-8) in COPD subjects. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens
3 We studied the role of PGE2, its biosynthetic enzymes and its receptors, in regulating the functions of lung fibroblasts through the production of Vascular Endothelial Growth Factor (VEGF) and Interleukin-8 (IL-8) in COPD subjects. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens
4 Low concentrations of synthetic PGE2 increased the release of VEGF in HFL-1, but higher concentrations were needed to induce the release of IL-8. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens
5 In the airways of COPD subjects, fibroblast-derived PGE2 may regulate angiogenesis and inflammation through the production of VEGF and IL-8 respectively, suggesting that the increase in expression of COX-2, EP2 and EP4 observed in COPD fibroblasts may contribute to steering the role of PGE2 from homeostatic to pro-inflammatory. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens