Title : Long Receptor Residence Time of C26 Contributes to Super Agonist Activity at the Human β2 Adrenoceptor.

Pub. Date : 2016 Apr

PMID : 26772612






1 Functional Relationships(s)
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1 We have further characterized the novel beta2 adrenoceptor agonist C26 (7-[(R)-2-((1R,2R)-2-benzyloxycyclopentylamino)-1-hydroxyethyl]-4-hydroxybenzothiazolone), which displays higher intrinsic activity than the endogenous ligand adrenaline in cAMP accumulation, beta-arrestin-2 recruitment, and receptor internalization assays. Cyclic AMP adrenoceptor beta 2 Homo sapiens