Title : An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response.

Pub. Date : 2016 Jan 12

PMID : 26715744






1 Functional Relationships(s)
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1 Mice treated with Nelfinavir display hallmarks of this stress response in the liver, including alpha subunit of translation initiation factor 2 (eIF2alpha) phosphorylation, activating transcription factor-4 (ATF4) induction, and increased expression of known downstream targets. Nelfinavir eukaryotic translation initiation factor 2A Mus musculus