Title : Decursin enhances TRAIL-induced apoptosis through oxidative stress mediated- endoplasmic reticulum stress signalling in non-small cell lung cancers.

Pub. Date : 2016 Mar

PMID : 26661339






1 Functional Relationships(s)
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1 CONCLUSIONS AND IMPLICATIONS: ROS generation by decursin selectively activated the PERK/ATF4 axis of the endoplasmic reticulum stress signalling pathway, leading to enhanced TRAIL sensitivity in TRAIL-resistant NSCLC cell lines, partly via up-regulation of DR5. Reactive Oxygen Species TNF receptor superfamily member 10b Homo sapiens