Pub. Date : 2016 Jul 28
PMID : 26616855
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Diacerein-mediated inhibition of IL-6/IL-6R signaling induces apoptotic effects on breast cancer. | diacerein | interleukin 6 receptor | Homo sapiens |
| 2 | Further molecular investigations indicated that diacerein instigated apoptosis was associated with inhibition of IL-6/IL-6R autocrine signaling axis. | diacerein | interleukin 6 receptor | Homo sapiens |
| 3 | Suppression of STAT3, MAPK and Akt pathways were also observed as a consequence of diacerein-mediated upstream inhibition of IL-6/IL-6R. | diacerein | interleukin 6 receptor | Homo sapiens |
| 4 | The docking study showed diacerein/IL-6R interaction that was further validated by competitive binding assay and isothermal titration calorimetry. | diacerein | interleukin 6 receptor | Homo sapiens |
| 5 | Taken together, diacerein offered a novel blueprint for cancer therapy by hampering IL-6/IL-6R/STAT3/MAPK/Akt network. | diacerein | interleukin 6 receptor | Homo sapiens |